Biochem/physiol Actions
Reversible: no
Product does not compete with ATP.
Primary TargetAurora B kinase
Target IC50: 95% inhibition at 10 µM using 1 µM; [ATP]
Cell permeable: yes
General description
A cell-permeable Erk Inhibitor II (Cat. No. 328007) structural analog that acts as a isoform-selective Aurora B kinase inhibitor (95% inhibition at 1 µM; [ATP] = 10 µM) with little or no activity against Aurora A or C (0% and 16% inhibition, respectively, at 1 µM; [ATP] = 15 µM), Also shown to inhibit Chk2, IRR/INSRR, and Ack1/TNK2 (% inhibition/[ATP] = 81%/70 µM, 75%/200 µM, and 71%/70 µM, respectively), while exhibiting much reduced or no inhibitory potency toward a panel of 228 other kinases, including Erk1/2.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Anastassiadis, T., et al. 2013. J. Biol. Chem.288, In press.Gao, Y., et al. 2013. Biochem. J.in press.Ohori, M., et al. 2005. Biochem. Biophys. Res. Commun.336, 357.
Packaging
1 mg in Plastic ampoule
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
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